Fisher information — where it appears
Named by 4 essays across one field — each of them below, with the objects they name alongside it.
A line on the macula's flank buys less than a repeated session
Fitted with six numbers, two sessions of colour matches keep a lens band and a moved macula apart, but the band at 445 nm pays for it: correlated with the macula's shift at 0.82, its standard error 1.8 times its value when the macula is not fitted. A moved macula changes its long flank past 470 nm, where no lens band reaches, so a third session — the LED against a lamp with a narrow line at 487 nm — was predicted to bring the correlation under 0.6 and the band's error within a quarter of its band-only value. The correlation falls to 0.80 and the error to 1.5 times. A third session that simply repeats the second does better on both errors. The flank line pins how much macular pigment there is, not where it peaks, and it ties the band's height to its centre. Moved to 465 nm, onto the macula's peak, the same session brings the band within about a fifth of its band-only error — but no position of the line brings the correlation below 0.78. The band at 445 nm and the macula's peak are told apart by their short flanks, and a third session adds matches rather than a new kind of evidence.
Knowing the macula's density frees two sessions, not the line on its peak
Fitted with six numbers, an older observer's colour matches cannot fully split a lens band at 445 nm from a macula whose peak has moved: their correlation stays above 0.78 under every third session tried. The proposal was to measure the macular pigment's density from outside the matches, leaving five numbers, and the prediction was that a line on the macula's peak would then split the pair below 0.6 while two plain sessions stayed near 0.8. It runs the other way. With the density known exactly, two sessions fall from 0.83 to 0.62 and the line at 465 nm only from 0.86 to 0.74. The density was the road the band and the peak traded along — correlated with each at about −0.75 in two sessions' fit — and the designs that had already narrowed that road gain least from closing it. A realistic outside measurement closes almost none of it: the matches already know the density to 0.027, so a flicker measurement good to 0.05 moves the correlation by three hundredths. And far from the macula, at 415 nm, a known density binds the band to the peak more tightly than before.
A density a tenth wrong costs the band more than fitting it
An older observer's colour matches carry a lens band and a macula that can trade against each other, and fixing the macular pigment's density from an outside measurement breaks much of that trade when the density is right. A flicker measurement and a colour match average the pigment over different fields, so the fixed density can be wrong by a tenth or more, and the prediction was that a tenth too high takes about a third of a standard error off a band at 445 nm and moves the macula's peak by under half a nanometre. It takes 1.4 standard errors off the band and moves the peak 1.25 nm short. At 415 nm the same error pushes the band the other way, up by 2.4 standard errors, and runs its fitted centre 5.6 nm shorter and the lens's age three years younger. Bias and error together, a density fixed a tenth wrong gives the band at 445 nm a larger error than leaving the density free; the break-even is about eight per cent. Given as a measurement with its own standard error of 0.03 instead of fixed, the same wrong density biases the band by under half its error.
A wrong density shifts every experiment alike near the macula
Read from the expected matches, a macular density fixed a tenth too high lowers an older observer's lens band at 445 nm by 1.4 of its standard errors and raises a band at 415 nm by 2.4. Real experiments carry noise, and the prediction was that their fits scatter about those biases with the fixed fit's own error, so that a tenth's mistake puts the band beyond twice its error in about a third of experiments at 445 nm and two thirds at 415. Twenty simulated experiments per case, each fitted with the density free and held at 0.9, 1 and 1.1 of its truth, give five of twenty at 445 nm and sixteen at 415 under two sessions — eight and eighteen with a line on the macula's peak. Near the macula the bias is a rigid shift: every experiment moves by the first-order amount to within a tenth of a standard error. Far from it the bias is lopsided — up by 0.058 for a density too high, down by 0.032 for one too low — and a density too low erases the band altogether in one experiment of twenty.
Named alongside it
The objects these essays reach for when they reach for this one.
IdentifiabilityLens yellowingMacular pigmentModelling assumptionStandard errorColour-matching functionsStandard observer